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18th International Conference on Structural Biology, will be organized around the theme “An Insight into Every Dimension of Advanced Structural Biology Research”

Structural Biology 2019 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Structural Biology 2019

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Structural Biology is the branch of biology which embarks the importance of biophysics and biochemistry in the molecular structure of biological macromolecules. It also provides information about the effect of structural alterations of macromolecules on their function. This process of determination of structures of proteinsnucleic acids may take years as the shape, size and assemblies of these molecules may be altering the function

  • Track 1-1Biochemistry
  • Track 1-2Structural modifications in nucleic acids
  • Track 1-3Biological system
  • Track 1-4Alternations in Protein Structure

Proteomics is the newest and the most discussed topic in the field of Structural Biology. It deals with determining the structure and function of proteins- the building blocks of the human body. It found its importance after the introduction of the Human Genome Project. Almost every process that occurs in our cells – from the metabolization of simple sugar to the division of cells – is dependent on proteins for smooth operation.
Genomics is the study of structure, working, mapping and alteration of genomes. The entire arrangement of DNA- the information centre of our body is known as genomics. Proteomics and Genomics are interrelated. Proteomics involve the study of structural determination of the body whereas Genomics involve the study of genetic makeup of the body.

  • Track 2-1Chemical & single cell proteomics
  • Track 2-2Molecular and cellular proteomics
  • Track 2-3Expression proteomics
  • Track 2-4Quantitative proteomics
  • Track 2-5Post-translational modifications & signal transduction
  • Track 2-6Cancer Genomics
  • Track 2-7Clinical Genomics
  • Track 2-8Comparative Genomics
  • Track 2-9Functional Genomics

Biochemistry is the study of chemical processes taking place inside the human body. Recently this subject has found its importance in the biological world as it has found its importance in all fields of life science and biology. By controlling information flow through biochemical signalling and the flow of chemical energy through metabolism, biochemical processes give rise to the complexity of life. Its main focus is to understand how biological molecules give rise to the processes that occur within living cells.

Biophysics is the trending topic in the field of biology. It relates physics and biology. In other words it signifies how traditional physical methods are used to study the biological phenomena inside the human body. Biophysical research shares significant overlap with biochemistry, molecular biology, physical chemistry, physiology, nanotechnology, bioengineering, computational biology, biomechanics and systems biology.

  • Track 3-1Systems Biology
  • Track 3-2Metabolomics
  • Track 3-3Biomolecules
  • Track 3-4Biophysical approaches to cell biology
  • Track 3-5Membrane Biophysics
  • Track 3-6Computational and theoretical Biophysics

Molecular Biology is a vast topic which deals with the structure and function of macromolecules. It is usually combined with techniques of Genetics and Biochemistry. Till 2000, Molecular genetics was the sub-field of Molecular Biology. Since Molecular Biology is mostly quantitative it’s in edge with computational biology and bioinformatics. Other zones of Biology focus directly or indirectly on molecules, whereas developmental biology and cell biology focus directly, while phylogenetic and evolutionary biology focus indirectly. Genetics deals with study of mutants and its comparison with the wild type (normal phenotype).

  • Track 4-1Genetics
  • Track 4-2Cell Biology
  • Track 4-3Developmental Biology
  • Track 4-4Gene Expression

Biomolecules are very small to see in detail even by most cutting-edge light microscopes. The methods that the structural biologists use to determine their structures in general involve the measurements on huge numbers of identical molecules at the same time. Some of the best methods include X-raycrystallography, cryo-electron microscopy and nuclear magnetic resonance. Apart from these methods there are many additional methods through which 3 D Structure Determination can be done.

  • Track 5-1X-ray crystallography
  • Track 5-2Nuclear Magnetic Resonances
  • Track 5-3Cryo-Electron Microscopy
  • Track 5-4Mass spectroscopy
  • Track 5-5Dual polarisation interferometry
  • Track 5-6Multi-angle light scattering Technique
  • Track 5-7Ultra-fast laser spectroscopy

Computational approaches are a boon for structural biology. These methods use the concepts of bioinformatics to determine the structure of macromolecules. In general the structure of molecules is determined by experimental methods is both time intense and cost effective. To overcome these constraints, computational approaches like ab-initio modelling, homology modeling and threading method are used.

  • Track 6-1Homology modeling
  • Track 6-2Ab-initio method
  • Track 6-3Threading
  • Track 6-4Discoveries through computational approaches

Molecular modelling involves the hypothetical and computational procedures which are used to mimic the behaviour of macromolecules. Molecular modelling techniques are used in various fields some of which are drug design, computational chemistry, materials science and computational biology. These methods are used for studying and understanding the properties of the molecules. One of the major applications of molecular modelling is molecular simulation. This is the technique which uses powerful computers to simulate the interactions between atoms and to understand the properties of materials. Such simulations involve methods that range from very detailed quantum mechanical calculations on atoms to coarse-grained classical dynamics of large groups of molecules on a timescale of milliseconds or longer.

Molecular dynamics (MD) deals with the study of physical movements of the atoms and molecules using computer simulation method, so it is referred to as one of the type of N-body simulation. The atoms and molecules are allowed to interact for a fixed period of time, giving a view of the dynamic evolution of the system. The trajectories of atoms and molecules are commonly determined by solving them numerically using Newton’s equations of motion for a group of collaborating particles. The forces between the particles and their potential energies are calculated using inter-atomic potentials or molecular mechanics force fields.

  • Track 7-1Steered Molecular Dynamics (SMD)
  • Track 7-2Potentials in ab-initio methods
  • Track 7-3Hybrid QM/MM
  • Track 7-4Protein Folding
  • Track 7-5Enzyme catalysis
  • Track 7-6Protein stability
  • Track 7-7Molecular recognition of proteins
  • Track 7-8DNA and membrane complexes

Drug designing is an inventive process to find new medication centred on the knowledge of biological target. Drug is most commonly a small molecule that inhibits or activates the function of a biomolecule, which in turn outcomes in a therapeutic benefit to the patient. Drug design commonly but not essentially relies on computational techniques. This type of modelling is often mentioned to as computer-aided drug design.

biomarker is an attribute that can be studied as an indicator of pathogenic and biological operation along with pharmacological retort to a therapeutic involvement. They indicate either normal or diseased activity in the body. Biomarkers are specific molecules, genes, gene products, hormones, cells or enzymes.

  • Track 8-1Drug targets
  • Track 8-2Ligand-based design
  • Track 8-3Structure-based design
  • Track 8-4Computer-aided drug design
  • Track 8-5Scoring functions

Signalling is the process through which the cells communicate with each other. They are often secreted from the cell and released into the extracellular space. Regulation of gene expression comprises a comprehensive range of mechanisms that are used by cells to regulate the production of specific gene products, and is familiarly termed as gene regulation. Sophisticated programs of gene expression are extensively observed in biology, for example to trigger developmental pathways, adapt to new food sources, or respond to environmental stimuli.

  • Track 9-1G-protein-coupled receptor
  • Track 9-2Adrenergic receptor
  • Track 9-3Protein crystallography
  • Track 9-4Protein structure

Enzymes play a crucial role in signalling the cellular and metabolic pathways. Research works are going on to identify, how the enzymes function at molecular and atomic level by combining the modern biochemistry and structural biology.

  • Track 10-1Calorimetric methods
  • Track 10-2Chemical analysis
  • Track 10-3Protein engineering
  • Track 10-4Protein prenylation techniques
  • Track 10-5Steady state kinetics

Sequence analysis can be explained as a process of exposing DNA, RNA or peptide sequence to a wide range of analytical methods in order to understand its structure, function and evolution. The methods include sequence alignment and biological databases. Synergistic use of three-dimensional structures and deep sequencing is done to realize the effect of personalized medicine. The usage of sequence analysis in structural biology will pave the way to new methods which can be utilized to determine the structure of molecules.

  • Track 11-1Profile comparision
  • Track 11-2Sequence assembly
  • Track 11-3Gene prediction
  • Track 11-4Deep sequencing for protein structure determination
  • Track 11-5Complementary Methods
  • Track 11-6Deep sequencing for cancer studies
  • Track 11-7Deep sequencing of HIV

This is a cost effective approach for determining the protein structure. The computational prediction methods, such as initiating fragment assembly, advanced fold recognition, composite approaches, and molecular docking are regularly applied in recent times to expand our understanding of protein structures. Hybrid approach is a channel to overcome these disadvantages, by incorporating limited experimental measurements, reliable structures can be computed and unlikely predictions are eliminated. The current researches are showing great interest in this method of approach.

  • Track 12-1NMR structures
  • Track 12-2Hybrid of experimental methods
  • Track 12-3Hybrid of computational methods
  • Track 12-4Hybrid approaches in complementing high-resolution structural biology
  • Track 12-5Determining protein complex structures
  • Track 12-6Bottom-up integration of atomic detail crystallography

Structural bioinformatics is an exceptionally cost effective solution for protein structure determination. Purely computational prediction methods, like ab initio fragment assembly, advanced fold recognition, composite approaches, and molecular docking are regularly applied today to extend our understanding of protein structures. However, predicted structures are not given the same reliance as their experimental complements. Hybrid approaches are a means to overcome these limitations; by incorporating limited experimental measurements, reliable structures can be computed and unlikely predictions eliminated. Hybrid approaches take advantage of data derived from a wide range of different biophysical and biochemical methods. These methods are of growing interest in current researches of structural biology.

  • Track 13-1Genome Mapping
  • Track 13-2Translational Medicine
  • Track 13-3Protein Modeling
  • Track 13-4Epigenomic data analysis
  • Track 13-5Computational Neuroscience
  • Track 13-6Mathematical Techniques

The main focus of a structural biologist is protein structure determination and drug design. Protein plays an important role in human body. Living things would not exist without proteins. The proteins are usually involved in all forms of expressions of the living organism. Most of the proteins are evolved in providing structure to the cell while the others tend to bin and carry vital molecules all through the body. Some proteins are involved in biochemical reactions in the body which are termed as enzymes. Others are involved in muscle contractions and immunity. Structure determination of proteins has always been a challenging filed. The complex areas in the field include viruses, pathogens, membrane proteins and signalling pathways. Novel progressions are being done in the arenas of nano-patternig and multi-scale modelling of cell signalling proteins.

  • Track 14-1Membrane proteins
  • Track 14-2Pathogens and viruses
  • Track 14-3Nano patterning
  • Track 14-4Macromolecular designing

The main aim of integrating structural biology data into cancer research is to design and discover novel and effective drugs to cure the disease. Structural biology combined with molecular modelling mainly aims at drug designing. Consequently, a number of Structural Biologists are conducting cancer research, to speed-up the process of understanding the mechanism of biomolecules in order to improve the newer cancer therapies.

Major part of research is being carried out in the area of cancer. The main aim is to design and discover novel and effective drugs to cure the disease. Structural biology combined with molecular modelling mainly aims at drug designing. Subsequently, numerous team leaders in Structural biology carry out cancer research to accelerate the exploitation of molecular understanding of biomolecules in the advancement of novel cancer therapies.

  • Track 15-1Cancer Systems Biology
  • Track 15-2Tumorigenesis
  • Track 15-3Cancer Heterogeneity
  • Track 15-4Epidemiology
  • Track 15-5Statistical and Mechanistic Modelling of Signalling Networks

Molecular techniques are used in molecular biology, biochemistry and genetics for the analysis of DNA, RNA and protein. Molecular cloning is the widely used molecular technique. The different methods in molecular biology are Haemocytometer cell counter, Restriction enzyme digestion, DNA ligation, transfection, western blot, plasmid purification, electroporation, heat shock method and ELISA.

  • Track 16-1DNA sequencing‎ 
  • Track 16-2Gene delivery
  • Track 16-3Microarrays‎ 

A database is an organised collection of data. As a result of enormous research which is being done in Structural biology massive data has been produced. In order to assemble the data in a catalogued manner, bioinformatics databases are used. Various databases have been created to store biological data, such as sequence databasesstructure databases, signalling pathway databases, etc.

A database is a structured collection of data. In the field of structural biology enormous research is being done and as a result massive data is being produced. In order to pile the data in an organized manner, bioinformatics databases are used. Various databases have been created to store biological data, such as sequence databases, structure databases, signalling pathway databases, etc. In the field of structural biology, the mainly used databases are Protein Data Bank (PDB), Electron Microscopy Data Bank, Protein Structure Classification Database (CATH) and Structural Classification of Protein (SCOP).

  • Track 17-1Classification of structural database
  • Track 17-2Classification of protein structure
  • Track 17-3Protein structure classification database
  • Track 17-4Protein data bank
  • Track 17-5Electron microscopy data bank

Structural biology is one of the progressing fields. In the course of time many developments have been taking place. Huge numbers of solved structures have exaggerated rapidly. The field of drug design and drug discovery has been advanced. Functional annotations are another field where progressions are rapidly evolving. Alterations in order to improve the effectiveness of prevailing tools can also be noted. Remarkable advances have been made in the areas of technical imaging and advancement of hybrid methods to understand the structure and function of proteins.

  • Track 18-1Advances In Drug Design
  • Track 18-2Advances In Tool Development
  • Track 18-3Advances In Imaging Technologies