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Ivan Barvík

Charles University, Czech Republic

Title: Computer modeling of TRPC channels gating

Biography

Biography: Ivan Barvík

Abstract

Statement of the problem: Transient Receptor Potential (TRP)-related channels are a large, diverse superfamily of proteins consisting of six families (TRPV, TRPC, TRPM, TRPA, TRPP, TRPML) and 30 subtypes [1-3]. TRP channels are activated by diverse cellular and environmental signals. Inhibition of TRP channels expressed on nociceptive neurons represents a viable therapeutic pain target. All TRP channels form functional tetramers, with each subunit consisting of six transmembrane segments (S1-S6) flanked by amino- and carboxyl-terminal cytosolic domains. The S1-S4 helices form isolated sensor domains arranged radially around the periphery of the central-ion conducting pore, which is lined with four S5-S6 domains. The central cavity involved in the ion permeation exhibits major constrictions at the selectivity filter, as well as at the lower gate. Unfortunately, not all TRP channels have their closed and open structure resolved.